Two under-pressure managers clash in a crucial London derby on Saturday, with both Thomas Frank and Nuno Espirito Santo in need of a win.
Spurs will be the favourites as they take on relegation-threatened West Ham, but there will be plenty of nerves on both sides.
Mohammed Kudus injury latest ahead of Tottenham v West Ham
Kudus has been out of action since suffering a thigh injury in his sides 1-1 draw with Sunderland on 4 January.
But a return against former club West Ham will not be happening, with the Ghana international set for a longer spell on the sidelines.
"Mohammed Kudus unfortunately is a bigger one to the tendon in the quad. That is one where we expect him back after the March international break, Frank said earlier this month.
The forward has struggled for consistency since making the �55m switch across London, scoring two goals and providing six assists in 19 league appearances.
West Ham, meanwhile, have struggled to replace Kudus, after his five goals and three assists in 32 league appearances last term helped them steer clear of the bottom three.
His continued absence is a blow for Spurs, who have several other injury concerns as they look to arrest their worrying form.
Rodrigo Bentancur, Richarlison, Lucas Bergvall, James Maddison and Dejan Kulusevski are all currently out, leaving Frank thin on options in attack.
Spurs have strengthened in midfield, though, with the signing of former Chelsea man Conor Gallagher from Atletico Madrid.
Franks side currently sit 14th in the Premier League and fans will demand immediate improvement.
West Ham are seven points adrift of safety after losing to Nottingham Forest last time out.
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