EmailPrintOpen Extended ReactionsThe complete 2026 NFL schedule has been released, and odds are already available for Week 1 and several other high-profile games.The Seattle Seahawks and New England Patriots will meet in a Super Bowl rematch in the NFL's season opener on Wednesday, Sept. 9. The defending champion Seahawks opened as 3.5-point home favorites.The international series gets going Thursday, Sept. 10, with an NFC West matchup between the Los Angeles Rams -- the current favorites to win the Super Bowl -- and rival San Francisco 49ers in Melbourne, Australia.The largest spread of Week 1 belongs to the Los Angeles Chargers, who are favored by 11.5 points over the Arizona Cardinals. The Chargers are the only double-digit favorite. Nine games have spreads of a field goal or less.The highest points total in Week 1 is the Tampa Bay Buccaneers-Cincinnati Bengals matchup (50.5).Here's a look at the early odds for every Week 1 game, as well as other highlights on the schedule that already have spreads.Odds by DraftKings Sportsbook and subject to change.Wednesday, Sept. 9New England Patriots at Seattle Seahawks (-3.5)8:20 p.m. ET on NBCMoneyline: Seahawks -192, Patriots +160Total: 44.5 pointsThursday, Sept. 10San Francisco 49ers vs. Los Angeles Rams (-2.5)Melbourne Cricket Ground, Melbourne, Australia8:35 p.m. ET on Netflix Moneyline: Rams -148, 49ers +124Total: 48.5 pointsSunday, Sept. 13Chicago Bears (-2.5) at Carolina Panthers1 p.m. ET on FOXMoneyline: Bears -135, Panthers +114Total: 44.5 pointsTampa Bay Buccaneers at Cincinnati Bengals (3.5)1 p.m. ET on FOXMoneyline: Bengals -198, Buccaneers +164Total: 50.5 pointsCheck out all 32 teams' Super Bowl odds, win total projections and more.Baltimore Ravens (-3.5) at Indianapolis Colts1 p.m. ET on CBSMoneyline: Ravens -185, Colts +154Total: 49.5 pointsBuffalo Bills (-1.5) at Houston Texans1 p.m. ET on CBSMoneyline: Bills -112, Texans -108Total: 45.5 pointsNew Orleans Saints at Detroit Lions (-7)1 p.m. ET on FOXMoneyline: Lions -325, Saints +260Total: 48.5 pointsNew York Jets at Tennessee Titans (-3)1 p.m. ET on CBSMoneyline: Titans -170, Jets +142Total: 39.5 pointsAtlanta Falcons at Pittsburgh Steelers (-3)1 p.m. ET on FOXMoneyline: Steelers -175, Falcons +145Total: 42.5 pointsCleveland Browns at Jacksonville Jaguars (-7)1 p.m. ET on CBSMoneyline: Jaguars -290, Browns +235Total: 40.5 pointsFantasy football season is coming. Create or join an ESPN league today!Arizona Cardinals at Los Angeles Chargers (-11.5)4:25 p.m. ET on CBSMoneyline: Chargers -625, Cardinals +455Total: 45.5 pointsGreen Bay Packers (-1.5) at Minnesota Vikings4:25 p.m. ET on CBSMoneyline: Packers -125, Vikings +105Total: 44.5 pointsMiami Dolphins at Las Vegas Raiders (-3)4:25 p.m. ET on FOXMoneyline: Raiders -175, Dolphins +145Total: 41.5 pointsWashington Commanders at Philadelphia Eagles (-5.5)4:25 p.m. ET on FOXMoneyline: Eagles -238, Commanders +195Total: 46.5 points Dallas Cowboys (-2.5) at New York Giants8:20 p.m. ET on NBCMoneyline: Cowboys -130, Giants +110Total: 48.5 pointsMonday, Sept. 14Denver Broncos at Kansas City Chiefs (-2.5)8:15 p.m. ET on ESPN/ABCMoneyline: Chiefs -155, Broncos +130Total: 42.5 pointsOther highlighted games with odds available"Thursday Night Football"Sept. 17: Detroit Lions at Buffalo Bills (-3, 52.5), 8:15 p.m. ET (Prime Video)(First game at the new Highmark Stadium)Thanksgiving EveGreen Bay Packers at Los Angeles Rams (-3.5, 49.5), 8 p.m. ET (Netflix)Thanksgiving DayChicago Bears at Detroit Lions (-2.5, 51.5), 1 p.m. ET (CBS)Philadelphia Eagles (-1.5, 49.5) at Dallas Cowboys, 4:30 p.m. ET (FOX)Kansas City Chiefs at Buffalo Bills (-2.5, 49.5), 8:20 p.m. ET (NBC)Christmas DayGreen Bay Packers at Chicago Bears (-1.5, 47.5), 1 p.m. ET (Netflix)Los Angeles Rams at Seattle Seahawks (-1.5, 47.5), 8:15 p.m. ET (FOX)
